The story centers around an ordinary girl, Dong Shan Cai (Shen Yue), who is accepted into the most prestigious university in the country, Ming De University. Shan Cai is a girl from a family that barely makes ends meet. Due to the nature of her personality, she immediately clashes with F4, an elite clique composed of the four most popular boys in the institution, especially its spoiled, rich and arrogant leader – Dao Ming Si (Dylan Wang). Gradually, Dao Ming Si falls deeply in love with Shan Cai, only to realize that she is in love with one of his best friends, Hua Ze Lei (Darren Chen).
Eventually, the four boys begin to acknowledge Shan Cai’s unyielding personality that is like her namesake: a weed that can never be brought down. Shan Cai begins to see the good in the boys, paving the way for friendships and an eventual romance. However, Dao Ming Si’s mother strongly disapproves of Shan Cai due to her social status and family background, thus the former doing all things in order to break Shan Cai and Dao Ming Si’s relationship.